Endocrine Abstracts

Introduction: The combination of poly/monostotis fibrous dysplasia, café-au-lait pigmentation of the skin and endocrine hyperfunction (mostly precocious puberty) is known as McCune–Albright syndrome (MAS), a genetic origin syndrome with low incidence. The molecular basis of MAS is a mosaic activating mutation of the α subunit of the G protein (Gsα) gene.We present a clinical case of a 10-year-old boy with partial MAS and GH-secreting ...

Aim: The aim of this study was to evaluate metabolic abnormalities in young adults getting treatments of acute lymphoblastic leukemia (ALL) and brain tumors (BT) in their childhood.Methods: We examined 50 patients in two groups. The group-1: 18 ALL-survivors (nine women and nine men). All of them received cranial irradiation in dose up to 18 Gy and chemotherapy. In group-2: 32 BT-survivors (14 women and 18 men) were included. All patients received cranio...

Aim: The aim of this study was to examine the incidence of metabolic abnormalities in adults getting treatments of brain tumors (BT) and acute lymphoblastic leukemia (ALL) in their childhood or adolescence.Methods: patients were divided in two groups. In group 1: 31 BT survivors (13 women and 18 men) were included. All patients received craniospinal irradiation up to 36 Gy and boost to the tumor up to 55 Gy and chemotherapy. The group 2: 18 ALL survivors...

The patients following craniospinal irradiation (CSI) in young ages due to posterior fossa tumors had high risk of hypopituitarism. The glucagon stimulation test (GST) may be used as alternative the insulin tolerance test (ITT) in the diagnosis of GH deficiency (GHD) and central adrenal insufficiency (CAI) when insulin-induced hypoglycaemia is contraindicated e.g. history of convulsions, coronary heart disease, also it can be carry out as an outpatient. The aim of this study w...

The glucagon stimulation test (GST) may be used as a good alternative to the insulin tolerance test (ITT) in the diagnosis of secondary adrenal insufficiency (SAI). The aim of the study was to compare the GST and ITT for diagnostic SAI, to define cortisol cut-off points and factors affecting the appearance of false positive results in young adults followed CSI.Subjects and Methods: A retrospective study of 28 patients (median age 19 [17; 23]) at least 2 ...

Abstract: The secondary adrenal insufficiency (SAI) is life-threatening disease. 30–50% of patients have SAI following craniospinal irradiation (CSI). The “gold standard” of SAI diagnosis is the insulin tolerance test but it is demanding for patient and medical staff. The simple and reliable test would allow to use ITT rarely. The aim was to evaluate probability of using DHEA-S in SAI diagnosis. 41 patient after CSI non-pituitary brain tumors survivor and 23 hea...

The number of the non-pituitary brain tumors survives increases and will be growing up in the future. Although the prevalence of secondary adrenal insufficiency (SAI) vary depending on the methods of diagnostic, we have a few data about their ACTH and DHAE-S status. The aim of our study was to describe the hypotalamic-pituitary-adrenal axis (HPAA) changes after craniospinal irradiation (CRT) and diagnostic utility basal cortisol (BC), DHAE-S, glucagon stimulation test (GST) in...

Hypercortisolism due to Cushing disease is an extremely rare condition in children under one year of age. We present a case of a 10-month-old boy with lung cystic dysplasia and pituitary blastoma (ACTH-secreting). The disease manifested with symptoms of hydrothorax due to cystic dysplasia of the right lung’s upper lobe. Surgical resection of the affected area has been carried out. Symptoms of endogenous hypercortisolism appeared soon after lung surgery. Cushing disease du...

Introduction: Craniopharyngiomas (CF)- benign epithelial tumors that develop from the remnants of Rathke’s pouch cells. Most often, CF manifest themselves in two age groups: in children 5–14 years old making 5.6–13% of intracranial tumors and in adults 50–74 years old making 2–5%.Materials and methods: In the last decade, the Institute annually for the surgical treatment received 100–120 patients with CF. The total number of...